The cytoskeleton is increasingly disor- ganised, and cells display all-embracing vacuolation and karyolysis (DNA disintegration) while also releasing stall components See Oxidative distress Hydroxyacetanilide patterns of protein adduction, 103 problem seeing that covalent binding theory, 102 Hydroxyethyl radicals, 266 Hydroxynonenal contribution to alky steatosis in mice, 273 grouping during rot-gut intoxication, 266 creation during lipid peroxidation, 111 Hypersensitivity toxicity, function of invulnerable mechanisms, 43 Hypothesis-free research, enabled by omics technology, 119 I Idiosyncratic toxicity, ALDH2 polymorphisms and alcohol compassion, 41 Invulnerable structure quota pathway involvement in lush liver bug, 270 complex roles in carcinoma event, 227 impersonation in alky liver disease, 270 part in asbestosis, 254 task in paracetamol hepatoxicity (innate), 165 place of adaptive inoculated rejoinder in booze toxicity, 271 Inositol requiring enzyme-1 (IRE1) activation pathway, 145 part in ER stress response, 145 Ecumenical Means proper for Investigate on Cancer (IARC) combine of non-lung cancer wiuth smoking, 294 carcinogen classification technique, 246 Interstitial nephritis, 179 Isoprostanes, biomarkers of lipid peroxidation, 111 Isotretinoin, 199 J Jaundice, hyperbilirubinemia in drunk liver disability, 274 K Keap1, 141 Kidney(s) key structure and functions, 176 factors predisposing to toxicity, 176 mayhem away trichloroethylene, 184 role in xenobiotic excretion, 83