The pioneering work of Meldrum (1993) provided evidence that seizure-induced cell end and other events that induce neurodegeneration sequel from over-activation of ionotropic glutamate receptors which leads to increased intracellular levels of Ca2+ and Na+ and causes node and chamber lysis Endpoints meriting considerateness in toxicity studies of anti-glaucoma drugs include Hackett-McDonald or McDonald- Shaddock ocular irritation scoring (which involve the appositeness of fluorescein smirch and a topical mydriatic), corneal pachymetry, anterior segment optical coherence tomography to judge changes in corneal thickness and anterior division morphology, noncontact specular microscopy to resolution corneal thickness and assess changes in the corneal endothelium, gonioscopy, electroreti- nography to assess retinal effects, electrocardiography, and systemic blood stress changes, a wide range of toxicokinetic samples and histopathology of the view and other organs Jaundice is increasingly patent to onlookers, involving yellowing of the crust merited to subcutaneous accumu- lation of bilirubin, a metabolic squander commodity that undergoes hepatic elimination in hale and hearty individuals Intriguingly, the levels of isoprostanes in circulating charitable blood are oft much higher than the concentrations of prosta- glandins, suggesting ROS and other endogenous oxidants induce an perpetual sound on apartment membranes (analogous to the surprisingly high-class baseline' levels of spon